Medicines

Here you will find the recommendations we have made about the use of individual medicines in Lancashire.

Ixekizumab

Brand: Taltz ®
NICE TA: 442
Indication: Ixekizumab for treating moderate to severe plaque psoriasis (NICE TA442)
Disease category: Skin
Commissioning responsibility: CCG
PbR excluded: Yes

Background

Ixekizumab is recommended as an option for treating plaque psoriasis in adults, only if:
•the disease is severe, as defined by a total Psoriasis Area and Severity Index (PASI) of 10 or more and a Dermatology Life Quality Index (DLQI) of more than 10
•the disease has not responded to standard systemic therapies, for example, ciclosporin, methotrexate and PUVA (psoralen and long-wave ultraviolet radiation), or these treatments are contraindicated or the person cannot tolerate them, and
•the company provides the drug with the discount agreed in the patient access scheme.

Stop ixekizumab treatment at 12 weeks if the psoriasis has not responded adequately. An adequate response is defined as:
•a 75% reduction in the PASI score (PASI 75) from when treatment started or
•a 50% reduction in the PASI score (PASI 50) and a 5‑point reduction in DLQI from when treatment started.

When using the PASI, healthcare professionals should take into account skin colour and how this could affect the PASI score, and make the clinical adjustments they consider appropriate.

When using the DLQI, healthcare professionals should take into account any physical, psychological, sensory or learning disabilities, or communication difficulties, that could affect the responses to the DLQI and make any adjustments they consider appropriate.

Decisions of Lancashire local decision making groups:

NHS Blackburn With Darwen CCG and NHS East Lancashire CCG NHS Blackpool CCG NHS Chorley and South Ribble CCG and NHS Greater Preston CCG NHS Fylde and Wyre CCG NHS Morecambe Bay CCG NHS West Lancashire CCG

Red

Red

Red

Red

Red

Red