Medicines

Here you will find the recommendations we have made about the use of individual medicines in Lancashire.

Prucalopride

Brand: 
NICE TA: 211
Indication: Treatment of chronic constipation in women (NICE TA211) and Use in men: Prucalopride for the treatment of chronic constipation in men (LMMG recommendation)
Disease category: Gastro-intestinal system
Commissioning responsibility: CCG
PbR excluded: No

Background

Use in women: NICE TA 211 (Prucalopride for the treatment of chronic constipation in women)
Prucalopride is recommended as an option for the treatment of chronic constipation only in women for whom treatment with at least two laxatives from different classes, at the highest tolerated recommended doses for at least 6 months, has failed to provide adequate relief and invasive treatment for constipation is being considered.
If treatment with prucalopride is not effective after 4 weeks, the woman should be re-examined and the benefit of continuing treatment reconsidered.
Prucalopride should only be prescribed by a clinician with experience of treating chronic constipation, who has carefully reviewed the woman’s previous courses of laxative treatments.

Use in men: Prucalopride for the treatment of chronic constipation in men
LMMG recommends prucalopride as an option for the treatment of chronic constipation in men for whom treatment with at least two laxatives from different classes, at the highest tolerated recommended doses for at least 6 months, has failed to provide adequate relief and invasive treatment for constipation is being considered.
If treatment with prucalopride is not effective after 4 weeks, the man should be re-examined and the benefit of continuing treatment reconsidered.
Prucalopride should only be prescribed by a clinician with experience of treating chronic constipation, who has carefully reviewed the man’s previous courses of laxative treatments.

Recommendation

LMMG recommendation: Amber0
Click here to find the definitions for the colour classifications

Reason for decision:  Suitable for GP prescribing following recommendation/initiation by specialist

Supporting documents:

NICE TA211 - Prucalopride for the treatment of chronic constipation in women

Constipation Pathway (Version 1.2) (665.1 KiB)

Decisions of Lancashire local decision making groups:

NHS Blackburn With Darwen CCG and NHS East Lancashire CCG NHS Blackpool CCG NHS Chorley and South Ribble CCG and NHS Greater Preston CCG NHS Fylde and Wyre CCG NHS Morecambe Bay CCG NHS West Lancashire CCG

Amber0

Amber0

Amber0

Amber

Amber0