Here you will find the recommendations we have made about the use of individual medicines in Lancashire.

Tapentadol modified release

Brand: Palexia ® SR
Indication: Pain in the non-palliative care setting
Disease category: Central nervous system
Commissioning responsibility: CCG
PbR excluded: No


Tapentadol MR is NOT recommended for use by the NHS in Lancashire in the following settings:
• as a treatment option for intractable neuropathic pain in non-palliative care patients.
• as a treatment for nonspecific pain
There is insufficient evidence to consistently demonstrate improved efficacy in the above settings when compared to opioid drugs and there is a lack of significant evidence to demonstrate efficacy in patients inadequately controlled on opioid drugs.


LMMG recommendation: Black
Click here to find the definitions for the colour classifications

Reason for decision:  Not recommended for prescribing on the NHS in Lancashire

Supporting documents:

New Medicine Assessment - Tapentadol for Non-palliative Neuropathic Pain (Version 2) (360.6 KiB)

Tapentadol MR for Non-specific pain Position Statement (272.1 KiB)

Decisions of Lancashire local decision making groups:

NHS Blackburn With Darwen CCG and NHS East Lancashire CCG NHS Blackpool CCG NHS Chorley and South Ribble CCG and NHS Greater Preston CCG NHS Fylde and Wyre CCG NHS Morecambe Bay CCG NHS West Lancashire CCG




Amber (as Pan Mersey)