Medicines

Here you will find the recommendations we have made about the use of individual medicines in Lancashire.

Ustekinumab

Brand: Stelara®
NICE TA: 456
Indication: Moderately to severely active Crohn’s disease after previous treatment (NICE TA456)
Disease category: Gastro-intestinal system
Commissioning responsibility: CCG
PbR excluded: Yes

Background

Ustekinumab is recommended, within its marketing authorisation, as an option for treating moderately to severely active Crohn’s disease, that is, for adults who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a TNF‑alpha inhibitor or have medical contraindications to such therapies.

The choice of treatment between ustekinumab or another biological therapy should be made on an individual basis after discussion between the patient and their clinician about the advantages and disadvantages of the treatments available. If more than 1 treatment is suitable, the least expensive should be chosen (taking into account administration costs, dosage and price per dose).

Ustekinumab should be given until treatment failure (including the need for surgery) or until 12 months after the start of treatment, whichever is shorter. People should then have their disease reassessed in accordance with NICE’s recommendations for infliximab and adalimumab for the treatment of Crohn’s disease to see whether treatment should continue.

Decisions of Lancashire local decision making groups:

NHS Blackburn With Darwen CCG and NHS East Lancashire CCG NHS Blackpool CCG NHS Chorley and South Ribble CCG and NHS Greater Preston CCG NHS Fylde and Wyre CCG NHS Morecambe Bay CCG NHS West Lancashire CCG

Red

Red

Red

Red

Red

Red