Liothyronine as an add-on treatment for refractory hypothyroidism despite adequate monotherapy with levothyroxine
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Liothyronine is NOT recommended for use by the NHS in Lancashire and South Cumbria in the following setting:
as an add-on treatment for refractory hypothyroidism despite adequate monotherapy with levothyroxine.
There is insufficient evidence to demonstrate efficacy in the above setting, availability of the drug is limited, adverse events are more prevalent than for levothyroxine monotherapy and there would be a considerable cost pressure to the health economy if prescribed for all patients with normal serum TSH levels and have persistent symptoms.
This colour classification is in agreement with the recommendations contained within the NHS England and NHS Clinical Commissioners guidance document ‘Items which should not routinely be prescribed in primary care: Guidance for CCGs‘ published in November 2017.
Reason for decision:
Not recommended for prescribing on the NHS in Lancashire & South Cumbria