Liothyronine as monotherapy for the chronic management of hypothyroidism
Prescribing within Primary Care — Black
Liothyronine is NOT recommended for use by the NHS in Lancashire and South Cumbria in the following setting:
as an add-on treatment for refractory hypothyroidism despite adequate monotherapy with levothyroxine:
There is insufficient evidence to demonstrate efficacy in the above setting, availability of the drug is limited, adverse events are more prevalent than for Levothyroxine monotherapy and there would be a considerable cost pressure to the health economy if prescribed for all patients with normal serum TSH levels and have persistent symptoms.
As monotherapy for the chronic management of hypothyroidism:
There is a paucity of evidence in the literature supporting the use of Liothyronine monotherapy for the management of hypothyroidism. Liothyronine is not licensed for the long-term management of hypothyroidism.
Reason for decision:
Not recommended for prescribing on the NHS in Lancashire & South Cumbria