Upadacitinib
Red
Brand:
Nice TA:
665
Commissioning responsibility:
CCG
PbR excluded:
Yes
BNF chapter:
Musculoskeletal system
Background
1.1 Upadacitinib, with methotrexate, is recommended as an option for treating active rheumatoid arthritis in adults whose disease has responded inadequately to intensive therapy with a combination of conventional disease-modifying antirheumatic drugs (DMARDs), only if:
• disease is severe (a disease activity score [DAS28] of more than 5.1) and
• the company provides upadacitinib according to the commercial arrangement.