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Canagliflozin

Green

Brand:

Invokana®

Nice TA:

390

Commissioning responsibility:

CCG

PbR excluded:

No

BNF chapter:
Endocrine system

Background

Canagliflozin, dapagliflozin and empagliflozin as monotherapies are recommended as options for treating type 2 diabetes in adults for whom metformin is contraindicated or not tolerated and when diet and exercise alone do not provide adequate glycaemic control, only if:
  • a dipeptidyl peptidase‑4 (DPP‑4) inhibitor would otherwise be prescribed and
  • a sulfonylurea or pioglitazone is not appropriate.
The LSCMMG recommends canagliflozin as the 2nd line ““gliflozin”” (1st line dapagliflozin or empagliflozin).

Recommendation

LSCMMG Recommendation:

Green

Reason for decision:

Suitable for initiation in primary care

Supporting documents:

Decisions of Lancashire local decision making groups

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Last Updated: 01 - Jun - 2016